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          Recombinant Mouse IFNA2 Protein
           
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          產(chǎn)品說明書
                  
          FAQ
                  
          COA
                  
          已發(fā)表文獻(xiàn)
                  
           
          產(chǎn)品簡介
          


          Interferon-alpha 2 (IFN alpha -2) is one of 14 subtypes within the IFN-alpha class of Type I Interferons (1). IFN-alpha class members signal through a common cell surface receptor complex composed of IFN-alpha R2 and IFN-alpha R1 subunits. As the first highly active IFN to be cloned and produced, IFN alpha -2 has become the prototypic IFN for academic and pharmaceutical research. Murine IFN-alpha 2 can eliminate cardiac viral load and protect cardiomyocytes from injury in animals infected with coxsackievirus B3 (CVB3). IFN alpha -2 derived mutants with reduced IFNR2 binding inhibited HIV replication and mutants with more IFNAR1 binding potentiated antiviral activity.
          


           
          


          性能參數(shù)
          


          
	
		
          
			
			
          Synonyms
          
			          		
			
			
          alpha-2a interferon; Ifa2; IFNA; IFNA2; IFNA2a; IFNA2b; IFNA2c; IFNAA; IFNalpha 2
          
			          		
		
          
		
          
			
			
          Uniprot No.
          
			          		
			
			
          P01573
          
			          		
		
          
		
          
			
			
          Source
          
			          		
			
			
          Mouse IFNA2 Protein is expressed from HEK293 without tag. It contains Cys24-Glu190.
          
			          		
		
          
		
          
			
			
          Molecular Weight
          
			          		
			
			
          The protein has a predicted 19.4 kDa
          
			          		
		
          
		
          
			
			
          Purity
          
			          		
			
			
          > 95% as determined by SDS-PAGE.
          
			          		
		
          
		
          
			
			
          Biological Activity
          
			          		
			
			
          Measured in an anti-viral assay using L-929 mouse fibroblast cells infected with encephalomyocarditis (EMC) virus. . The EC50 for this effect is 20-200pg/mL.
          
			          		
		
          
		
          
			
			
          Endotoxin
          
			          		
			
			
          < 0.01 EU per 1μg of the protein by the LAL method.
          
			          		
		
          
		
          
			
			
          Formulation
          
			          		
			
			
          Dissolved in sterile PBS buffer.
          

			
          This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening.
          
			          		
		
          
		
          
			
			
          Concentration
          
			          		
			
			
          0.2 mg/mL
          
			          		
		
          
	          

          


           
          


          儲(chǔ)存條件
          


          The product should be stored at -85~-65℃ for 1 year from date of receipt.
          


          Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
          


           
          


          注意事項(xiàng)
          


            
	
          1. Please operate with lab coats and disposable gloves,for your safety.   
            2. 
	
          2. This product is for research use only. 
            3. 

          


          Ver. CN20240202
          


           
          

             
           
           
           
           
           
           
           
          400-6111-883