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          Phospho-JNK (Thr183/Tyr185) Rabbit pAb
           
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          產(chǎn)品說(shuō)明書(shū)
                  
          FAQ
                  
          COA
                  
          已發(fā)表文獻(xiàn)
                  
           
           
          


          The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
          


           
          


          產(chǎn)品性質(zhì)
          


          
	
		
          
			
			
          別名
          
			          		
			
			
          AI849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; EC 2.7.11.24; JAK 1A; JAK1A; JNK 1; JNK 46; JNK; JNK-46; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; MAPK8; Mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; MK08_HUMAN; p54 gamma; PRKM 8; PRKM8; Protein kinase JNK1; Protein kinase; mitogen-activated; 8; SAPK 1; SAPK gamma; SAPK1; Stress activated protein kinase JNK1; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1; Tyrosine protein kinase JAK1 .
          
			          		
		
          
		
          
			
			
          SwissProt ID
          
			          		
			
			
          P45983
          
			          		
		
          
		
          
			
			
          基因ID
          
			          		
			
			
          5599
          
			          		
		
          
		
          
			
			
          免疫原
          
			          		
			
			
          The antiserum was produced against synthesized peptide derived from human JNK1/2/3 around the phosphorylation site of Thr183 and Tyr185. AA range:151-200.
          
			          		
		
          
		
          
			
			
          緩沖液
          
			          		
			
			
          Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
          
			          		
		
          
		
          
			
			
          分子量
          
			          		
			
			
          Calculated MW: 48 kDa; Observed MW：46, 54 kDa
          
			          		
		
          
		
          
			
			
          克隆類型
          
			          		
			
			
          Polyclonal Antibody
          
			          		
		
          
		
          
			
			
          宿主
          
			          		
			
			
          Rabbit
          
			          		
		
          
		
          
			
			
          物種反應(yīng)
          
			          		
			
			
          Human, Mouse, Rat, Chicken
          
			          		
		
          
		
          
			
			
          推薦應(yīng)用
          
			          		
			
			
          WB, IHC, ICC/IF, ELISA
          
			          		
		
          
		
          
			
			
          純化方式
          
			          		
			
			
          Affinity Purified
          
			          		
		
          
	          

          


           
          


          應(yīng)用
          


          稀釋比 WB：1/500-1/1000；IHC: 1/50-1/100; IF: 1/50-1/200; ELISA: 1/10000
          


           
          


          儲(chǔ)存條件
          


          -25~-15℃保存
          


           
          


          注意事項(xiàng)
          


          1. 避免反復(fù)凍融。
          


          2. 本產(chǎn)品僅作科研用途。
          


          3. 為了您的安全和健康，請(qǐng)穿實(shí)驗(yàn)服并佩戴一次性手套操作。
          


           
          


          產(chǎn)品數(shù)據(jù)
          


          


          Ver.CN20230907
          


           
          

             
           
           
           
           
           
           
           
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